When to take sermorelin

Night, and nothing else

The sellers that print a time all print the same one: 22 of the 88 sermorelin pages we hold put the dose at night, at bedtime or in the evening. None puts it in the morning, and 66 say nothing about the time of day at all.

• Arc-1
• ARSYNL Rx
• Ascend Vitality
• Auren Rx
• Garcia Weight Loss, Aesthetics & Hormone Therapy
• Get Thin MD
• Ivy Rx
• Kongo
• LaSara Medical Group
• Liberty
• Maves
• Maximus
• Meto
• Obu Health
• PepHaūs
• Strut Health
• Sunlight
• The Edit
• Vytora Health
• WePeptideRx
• YOURx Health
• Yucca Health

A further 3 pages use a night word without giving a time: two promise better sleep “at night”, and VigorMeds’s line about “morning or evening routines” is about its nasal sprays and sublingual drops across a whole catalog, not about sermorelin. They aren’t counted.

The morning turns up once, as a question. Liberty asks “Should I inject sermorelin in the morning or at night?” in an FAQ whose answer is behind a click, a few lines below its own schedule, which says bedtime.

The reason sellers give

Of the 22, 9 say why, and they all give the same reason in nearly the same words: a night dose lines up with the body’s own night-time release of growth hormone. Sunlight puts it most simply.

The body-clock part is real physiology. Growth hormone rises during sleep, and a 2004 study that blocked growth hormone–releasing hormone overnight in healthy young men concluded that “endogenous GHRH is indispensable for the nocturnal augmentation of GH secretion” (Jessup et al., 2004). Sermorelin is a copy of that hormone, so the premise holds.

The step from there to the dose is the part no study in the record tests. Whether a night dose does more than a morning one is a comparison, and none of the trial abstracts filed under sermorelin in PubMed makes it (PubMed). What one study does show is how short a single dose is: given into a vein in healthy men, “Although GHRH(1-29)-NH2 was rapidly eliminated after intravenous injection, GH levels were elevated for about 3 hours.” (Wilton et al., 1993).

What the trials did

The trials in children picked bedtime too. The Geref International Study Group’s trial of the approved version treated 110 children for up to a year with a daily injection “given at bedtime” (Thorner et al., 1996), and a smaller study of eleven children with short stature gave it “each evening” (Hernández et al., 1988).

Those were children with growth hormone deficiency or short stature, in trials from 1988 and 1996, and neither abstract says why bedtime was chosen or compares it with another hour. No study in the record compares one hour with another, for a drug approved to treat only children or for the adults it’s now sold to.

A time is also only half a schedule. On 5 of the 88 pages the dose is limited to five days a week, so two sellers printing the same nightly figure can mean different monthly amounts of the drug, and only 15 of 89 sellers say how much drug the price buys in the first place.

Questions